The structure and cannabinoid receptor affinity of the aminoalkylindole AM-2233 was first reported in 2001, the compound contains a chiral carbon center in the 2-position of the piperidine ring with the (R)-enantiomer possessing 0.2nm affinity for the CB1 receptor and the (S)-enantiomer displaying reduced affinity. Aside from its high in vivo potency and iodine substituent that can be used for isotopic labeling AM-2233 has a remarkable ability to induce tinnitus in those who smoke it. Below is a collection of anecdotal reports.
Shockwaves went down my arms, swim could hear an extremely loud ringing in my ears as swim felt his whole body go numb and feel like the threads of my body start to come a part, it litterly felt I was about to die....First his hearing started to become muffled like as the ringing grew louder, and his vision continued to get dimmer and dimmer....Yes a strong ringing, actually when swim started to lose his hearing an overwhelming ringing came in....it does have potential though, but swim is wondering whats causes the hearing, and what other receptors does it act on to do that?
-godlike1213, November 2011
...the ringing/hearing loss effect really seems to be a distinctive characteristic of AM-2233. I personally disliked it, and am not looking forward to try this particular substance ever again. Except maybe in combination of some other cannabinoid(s), in small quantity.
-fehs, November 2011
The hearing going out and a ringing in my ears worse than after DeadMau5 concert was always in the way of enjoying AM-2233's effects. It gave SWIM a lot of anxiody. For days after having tested 1/2 a gram on Damiana blend SWIM was still questioning his hearing and thought there was ringing....SWIM will never see to further research with AM-2233, SWIM know's all he wants to about it, and thinks it may be quite toxic in some way. I also want to know what receptor is it affecting to alter hearing depth so dramaticly, and how potentially hazardous this RC possible is.
-CkenX, November 2011
My feline friend Ziggui and her friends dubbed AM-2233 "Tinnitus Powder".. lol. She said the horrible ringing always got in the way, and when she ran out of AM-2201 and was awaiting the new batch, she stated that AM-2233 was no where near even a temporary replacement for AM-2201, She is truly opposed to further research on this RC.
-d42kn355, May 2012
Swim does confirm the humming in my head around the sides it is a lil annoying what causes the humming that is interesting to me...swim said that last night the effects of buzzing humming ears last longer than sleeping 6 hrs and said the humming was still slightly present maybe the rc binds to more than cb receipters if sound travels to the brain by chemistry than am2233 could be binding on audiotory transmitters causing a hum thank god it is just a humming sound you can audiably hear and feal but not some lil prick talking in your head haha
-Ynot, September 2011
...the humming effect wasn't really bothering me much at first but when the dosage was increased even further the auditory effect changed; not only was my ears humming like before but now everything was also heavily 'muffled', kind of if I was covering my ears with my hands or something.
-fehs, September 2011
After the whole ordeal, a distinct ringing in both ears could be heard. Hearing also felt muffled as if coming home from a concert. This ringing remained persistant and induced some worry. Quickly with the internet experiences I learned ringing or "humming" is duely noted from a handfull of people. This confirmed the sample to be AM-2233 for sure....AM-2233 smoked off a blend is much more pleasant, with less "yuky" OD feeling, and less ringing in the ears/feeling of needing to "pop". Further research shall be conducted.....Ringing and buzzing is present, it seems, at possibly all/any dose. Hate to admit it, but AM-2233 is surprisingly potant in its own fashion.
-CkenX, September 2011
With 2233, I would describe it more like loss of hearing than humming. Kind of if you held your hands on your ears or something....with 2233, the "humming effect" was very different, and so distinctive feature... and it happened every time when I exceeded certain size of doses, and became more intense the more I kept smoking, while there clearly was no typical symptoms of cannabinoid overdose in the air....Not necessarily at the lowest doses, or to a small extent only, but it didn't take very much either, certainly doesn't require "od-levels" to achieve a strong dampening effect. No hallucinations really, just rather boring dulling of normal sounds... well, with a twist maybe, but not a twist large enough for me to call it hallucination.
-fehs, January 2012
Theirs AM-2233 I've brought from a site in the UK. It's not a bad buzz,it gets you stoned for about a hourish,more of a Sativa feeling to it,the only problem I noticed was a ringing sound in the ears,slightly off putting.
-pickledshrooms, November 2011
I really strongly reccomend against using am-2233, it is not a nice high and you get thee loudest ringing in your ears. Its just one of those 'unpleasent' synth highs but 90% of the time you smoke it.
-OTGee, March 2012
...had a massive overdose, parachuting 300 milligrams (i thought i was consuming a different chemical for which that amount would be a low dose) -aside from the horrible psichedelic like dying bad trip, gf fearing i had gone permanently insane- i went deaf for a whole day with horrible tinnitus
-cosmic._.ape, December 2012
...been there done that with said noid [AM 2233] my self i woke one morning after smoking it could not get of the bed painic attacks ring in the ears the works.
-foolsgold, December 2012
But since then I have been noticing little things that arn't quite right. For example Id say almost every day I have a pounding headache, I feel as if I have an irregular heartbeat although I went to doctors and they checked my blood pressure and said it was fine? I have also had unbearable tinnitus and iv heard that am2233 can lead to this?
-AphexSwim, May 2012
Personally I couldn't consume much 2233 due to the ridiculously high vape temp which seemed to be so close to the pyrolysis temp it was unreal, big cloulds of indoly smoke, also the tinnitus it gave me was horrid, first RC I've ever binned!
-hx_, March 2012
There is a new incense blend being sold retail in Australia that causes a loud ringing sensation in the ears that starts an hour after use. The ringing last for a couple of hours and is really annoying. A few different people have reported this now and it has been reported to the manufacturer without a response….Some people have reported AM-2233 causes ringing in the ears.
-nekointheclouds, June 2012